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VERSION:2.0
CALSCALE:GREGORIAN
PRODID:UW-Madison-Physics-Events
BEGIN:VEVENT
SEQUENCE:0
UID:UW-Physics-Event-1008
DTSTART:20080129T180500Z
DURATION:PT1H0M0S
DTSTAMP:20260423T072226Z
LAST-MODIFIED:19700101T060000Z
LOCATION:4274 Chamberlin Hall
SUMMARY:Cluster optimization in protein docking\, Chaos & Complex Syst
 ems Seminar\, Julie Mitchell\, UW Department of Mathematics
DESCRIPTION:Recent progress in obtaining docked protein complexes will
  be discussed. The combination of exhaustive search\, clustering and l
 ocalized global optimization can reliably find energy minima to highly
  nonconvex biomolecular energy functions.  Using an energy function th
 at adds desolvation and screened electrostatics to classical molecular
  mechanics potentials\, the global minimum is found very near to the o
 bserved native state.  This is demonstrated across a large number of b
 enchmark examples.
URL:https://www.physics.wisc.edu/events/?id=1008
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