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VERSION:2.0
CALSCALE:GREGORIAN
PRODID:UW-Madison-Physics-Events
BEGIN:VEVENT
SEQUENCE:0
UID:UW-Physics-Event-3427
DTSTART:20140916T170500Z
DTEND:20140916T180000Z
DTSTAMP:20260314T205201Z
LAST-MODIFIED:20140828T220915Z
LOCATION:4274 Chamberlin Hall (Refreshments will be served)
SUMMARY:Cyclin-dependent kinase-confined cortical chaos\, Chaos & Comp
 lex Systems Seminar\, Bill Bement\, UW Department of Zoology
DESCRIPTION:Cytokinesis--the final step in cell division--is restricte
 d to a discrete point in the cell division cycle referred to as "C-pha
 se". In C-phase\, the cortex of the cell is uniquely competent to resp
 ond to signals from the spindle by assembling the cytokinetic apparatu
 s. C-phase follows anaphase onset and varies in length according to ce
 ll type. We have discovered that anaphase onset in frog and echinoderm
  embryos is associated with cortical excitability\, manifest as waves 
 of Rho activity and F-actin that traverse the underside of the plasma 
 membrane. The waves are suppressed by cyclin dependent kinase 1 (Cdk1)
  and can be driven into a chaotic form when Cdk1 activity is experimen
 tally suppressed. Remarkably\, the excitability entails F-actin mediat
 ed Rho inhibition. We propose that C-phase is explained by the develop
 ment of cortical excitability which is normally restricted to a discre
 te portion of the cell cycle Cdk1 and that excitability provides the c
 ell with the means to balance the conflicting needs of speed\, precisi
 on and flexibility during cell fission.<br>
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URL:https://www.physics.wisc.edu/events/?id=3427
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