BEGIN:VCALENDAR
VERSION:2.0
CALSCALE:GREGORIAN
PRODID:UW-Madison-Physics-Events
BEGIN:VEVENT
SEQUENCE:6
UID:UW-Physics-Event-5147
DTSTART:20190920T203000Z
DURATION:PT1H0M0S
DTSTAMP:20260414T124408Z
LAST-MODIFIED:20190917T184451Z
LOCATION:2241 Chamberlin Hall
SUMMARY:Work and Dissipation in the Cell Cytoskeleton\, Physics Depart
 ment Colloquium\, Michael Murrell\, Yale
DESCRIPTION:Living cells generate and transmit mechanical forces over 
 diverse time-scales and length-scales to determine the dynamics of cel
 l and tissue shape during both homeostatic and pathological processes\
 , from early embryonic development to cancer metastasis.  These forces
  arise from the cell cytoskeleton\, a scaffolding network of entangled
  protein polymers driven out-of-equilibrium by enzymes that convert ch
 emical energy into mechanical work.  However\, how molecular interacti
 ons within the cytoskeleton lead to the accumulation of mechanical str
 esses that determine the dynamics of cell shape is unknown.  Furthermo
 re\, how cellular interactions are subsequently modulated to determine
  the shape of the tissue is also unclear.  To bridge these scales\, ou
 r group in collaboration with others\, uses a combination of experimen
 tal\, computational and theoretical approaches.  On the molecular scal
 e\, we use active gels as a framework to understand how mechanical wor
 k is produced and dissipated within the cell cytoskeleton.  On the sca
 le of cells and tissues\, we abstract mechanical stresses to surface t
 ension in a liquid film and draw analogies between the dynamics of wet
 ting and the dynamics of simple tissues.  Together\, we attempt to dev
 elop comprehensive description for how cytoskeletal stresses translate
  to the physical behaviors of cells and tissues with significant pheno
 typic outcomes such as epithelial wound healing.  
URL:https://www.physics.wisc.edu/events/?id=5147
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