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PRODID:UW-Madison-Physics-Events
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SEQUENCE:0
UID:UW-Physics-Event-5206
DTSTART:20191029T170500Z
DTEND:20191029T180000Z
DTSTAMP:20260415T175340Z
LAST-MODIFIED:20190923T190308Z
LOCATION:4274 Chamberlin (refreshments will be served)
SUMMARY:The role of auditory hair cells in frequency discrimination\, 
 Chaos & Complex Systems Seminar\, Robert Fettiplace\, UW Department of
  Neuroscience
DESCRIPTION:Hair cells\, the sensory receptors of the vertebrate inner
  ear\, convert incident sound stimuli into electrical signals. They al
 so separate the sound frequency components along the cochlea behaving 
 like an acoustic prism. Frequency analysis underlies the ability to id
 entify environmental sounds and categorize conspecific calls\, and is 
 implemented by two distinct mechanisms.  In all vertebrates except mam
 mals\, the hair cell receptor potential is electrically tuned by volta
 ge-dependent membrane ion channels\, but this process has a limited up
 per frequency range of a few kHz. In mammals\, broad mechanical tuning
  is augmented by contractions of outer hair cells\, underpinned by the
  piezoelectric protein prestin.  Both mechanisms are supported by grad
 ients in hair cell properties along the cochlea.  Examples of such gra
 dients include the numbers and types of voltage-dependent potassium ch
 annel and of the mechanically-sensitive transducer channel. An importa
 nt clinical correlate is that hair cells tuned to high frequencies are
  much more vulnerable to damage by noise and ototoxic agents\, and are
  the first to be lost with aging.
URL:https://www.physics.wisc.edu/events/?id=5206
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