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Part 2: Targeted searches for indirect dark matter signals in the direction of Milky Way satellite galaxies provide some of the strongest current constraints on the annihilation cross section of dark matter derived from gamma-ray observations. Milky Way satellite galaxies have the advantages of low astrophysical backgrounds, the ability to constrain the dark matter abundance and distribution from the kinematics of member stars, and the opportunity to combine observations of multiple satellites in a joint-likelihood framework to enable more sensitive analyses. Accordingly, the discovery of additional Milky Way satellites in wide-field optical imaging surveys may provide substantial advances for indirect dark matter searches. I will discuss a matched-filter maximum-likelihood algorithm to search for and characterize ultra-faint galaxies in the ongoing Dark Energy Survey, which will cover 5000 square degrees in the relatively less explored south Galactic cap.