Abstract: The origins, acceleration mechanism(s), and propagation of high energy cosmic rays within the galaxy have been a mystery for nearly 100 years. Today's experiments are beginning to provide a more complete and definitive answer to these classic questions. I will discuss one such: the Cosmic Ray Energetics And Mass (CREAM) balloon-borne experiment. CREAM uses a complementary set of charge, energy, and tracking detectors on successive balloon flights around the Antarctic continent to directly measure individual CR nuclei's spectra over 5 orders of magnitude in energy. These spectra provide clues to CR origins and acceleration mechanisms. To better understand CR propagation, we have extended the Boron to Carbon ratio over an order of magnitude higher in energy than previous measurements. I will then explore a few ways ongoing and upcoming detections of CR signatures with gamma-ray and neutrino detectors may shed further light on the classic CR questions, both through direct and indirect detection.