Abstract: Neutrinos are unique messengers from the high-energy universe. They can escape dense astrophysical environments, undeterred by intervening matter and radiation fields. The detection of high-energy astrophysical neutrinos in the TeV-PeV range by IceCube allows us to probe extreme cosmic sources and understand their emission processes in ways what would not be possible with photons alone. Enabling neutrino astrophysics in the coming decade will rest not only on the construction of new, more sensitive facilities, but also on the combined operation of multiple observatories capable of identifying additional tracers of hadronic emission. I will present a short overview of recent highlights from the neutrino sky and introduce a vision for how the coordinated operation of current and future multi-messenger observatories will help us deliver answers to some of the most pressing questions in high-energy astrophysics.