Events at Physics
Events on Tuesday, September 18th, 2012
- Chaos & Complex Systems Seminar
- The discovery of the ER-based acetylation machinery: from aging to Alzheimer's disease ... cancer too?
- Time: 12:05 pm
- Place: 4274 Chamberlin (refreshments will be served)
- Speaker: Luigi Puglielli, UW Department of Medicine
- Abstract: Our group recently reported that mammalian cells are able to acetylate the Ne-lysine residue of nascent membrane proteins in the lumen of the endoplasmic reticulum (ER). This event was initially discovered while studying the mechanisms that regulate the levels of b-site APP cleaving enzyme 1 (BACE1), a type I membrane protein that is involved in the pathogenesis of AlzheimeraEuroTMs disease. However, it is now clear that this process is not limited to BACE1. In fact, other membrane and secreted proteins as well as ER-resident proteins that are involved with synthesis and folding of nascent proteins in the ER lumen are also acetylated. Here, I will describe the biochemical properties of the individual components of the ER-based acetylation machinery and their impact on different neurodegenerative diseases, including AlzheimeraEuroTMs disease and spastic paraplegias. I will also discuss the initial characterization of a newly-generated animal model showing a possible impact of the ER-based acetylation machinery on the biology of the immune system as well as the risk for cancer.
- Host: Sprott
- Careers for Physicists
- Time: 4:00 pm
- Place: 4274 Chamberlin Hall
- Speaker: Dai Dee Pun, Skyline Solar
- Abstract: Dai Dee Pun obtained her PhD in Experimental Nuclear Physics from the University of Wisconsin in 1987. Since then, she has worked in a variety of companies, from startup to the world's largest semiconductor equipment company, Applied Materials. She is now the Director of Quality and Reliability at Skyline Solar, a startup company in the Silicon Valley working on enabling affordable utility scale solar energy using concentrated photovoltaic technology. She will tell us about her career as a physicist in the high tech industry in the Silicon Valley, in startups, small, and large corporations, and you will have ample opportunity to ask her questions.
- Host: Reina Maruyama