Abstract: The development of microscopic detection of ensembles of neutral atoms has transformed our ability to study complex many-body systems. Techniques like quantum gas microscopy and optical tweezer arrays grant a unique single-particle-resolved perspective on solid-state analogs and idealized quantum spin models, as well as novel detection capabilities for quantities like entanglement. In this talk, I will describe our progress towards developing these tools for a new atomic species, strontium. In doing so, we establish new prospects enabled by the rich internal degrees-of-freedom associated with alkaline-earth atoms. I will report on our recent results in which we apply our platform to optical atomic clocks, a new application of optical tweezer arrays which indicates a number of strengths for metrology. In particular, I will describe our strategies for reaching arrays with hundreds of tweezers with sub-Hz atom-optical coherence, 41 seconds of atomic coherence, and atomic stability on par with the state-of-the-art. I will then describe our parallel progress towards engineering entanglement on an optical clock transition, as well as new scaling strategies involving atom-by-atom assembly in optical lattice potentials.